Gas sensor and gas-measuring device for detecting volatile organic compounds

ABSTRACT

A gas sensor  10  has a measuring channel  11  with a gas inlet  12  and with a gas outlet  13,  at least one receptor layer  20,  a reference electrode  30  and a voltage-controlled analysis unit  50.  The reference electrode  30  is capacitively coupled with the receptor layer  20.  The reference electrode  30  is connected to the analysis unit  50  in an electrically conductive manner. The receptor layer  20  is formed in measuring channel  11.  The measuring channel  11  forms a dielectric layer between the receptor layer  20  and the reference electrode  30.  The receptor layer  20  has a support  21  and an analyte-binding layer  22.  The present invention provides for the analyte-binding layer  22  to be a self-assembling monolayer (SAM).

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a United States National Phase Application ofInternational Application PCT/EP2015/002211, filed Nov. 4, 2015, andclaims the benefit of priority under 35 U.S.C. §119 of GermanApplication 10 2014 016 394.6, filed Nov. 7, 2014, the entire contentsof which are incorporated herein by reference.

FIELD OF THE INVENTION

The present invention pertains to a gas sensor, to a gas-measuringdevice and to the use of a gas sensor according to the present inventionfor detecting volatile organic compounds.

BACKGROUND OF THE INVENTION

Gas sensors that are suitable for detecting chemical compounds comprise,in principle, a combination of receptor and transducer. Thereceptor—e.g., a receptor electrode—can typically interact with theanalyte molecules to be detected at the molecular level. Aphysicochemical property of the receptor, for example, the work functionof the receptor surface, changes in the process. The transducer candetect this change and transform it into a—for example,electrical—signal. The electrical signal can then, in turn, be used totrigger an alarm or the like.

For example, semiconductor-based gas sensors are known in thisconnection, which comprise a field-effect transistor (FET) and acapacitor coupled with the FET (Capacitively Controlled Field EffectTransistor (CCFET)). The capacitor is configured as an air capacitor.One of the two capacitor areas acts as a receptor, the surface of thecapacitor area (receptor surface) being able to interact with theanalyte molecules to be detected. The measured gas to be tested flowsthrough the capacitor between the capacitor areas and forms thedielectric. If an interaction occurs between the receptor surface andanalyte molecules, which are present in the gas being measured, thecapacitance of the capacitor changes. This change in capacitance can betransformed into an electrical signal by means of the FET.

U.S. Pat. No. 4,411,741 A provides in this connection a gas sensor, inwhich a receptor electrode is arranged opposite the gate electrode of anFET and is separated from the gate electrode by an air gap. The gateelectrode of the FET and the receptor electrode form the capacitor areashere.

DE 43 33 875 A1 also provides for a semiconductor gas sensor with anFET. However, the analyzing FET or the air gap, in which the layer isarranged, and the air gap, in which the gas-sensitive layer is formed,i.e., the capacitor, are nevertheless electrically coupled with oneanother. The FET has a gate electrode, which is connected to a sensorelectrode in a conductive manner. A gas-sensitive layer is arrangedopposite the sensor electrode. The gas-sensitive layer is spaced fromthe sensor electrode by an air gap and is coupled to the sensorelectrode capacitively via the air gap.

EP 2 006 668 A1 likewise provides for such a sensor. The gas-sensitivelayer is covered by an additional protective layer here. This additionalprotective layer is adheringly connected to the gas-sensitive layer, butis permeable to the target gas. This is likewise used to modify stronglynonlinear changes in the measured signal, which changes may occur incertain combinations of gas-sensitive layer and analyte despite a moreor less linear change in the target gas concentration, such that thechange in the measured signal more or less corresponds to the change inthe target gas concentration.

Typical materials of which the receptor layer of such prior-art gassensors may consist are metals, semiconductors, semiconductor compoundsor metal compounds, e.g., platinum, palladium, titanium nitride, copperphthalocycanine, barium titanate, tin dioxide, silver oxide, cobaltoxide, chromium-titanium oxide, gold, potassium iodide or alsogermanium. The particular material used determines what analytes can bedetected. For example, hydrogen can be detected by means of platinum orpalladium, while NO₂ and other inorganic gases can be detected, amongothers, with receptor layers consisting of cobalt oxide, tin oxide orcopper phthalocyanine The detection of so-called volatile organiccompounds is often problematic, especially if they have a generallyrelatively inert behavior, e.g., benzene. One reason for this is thefact that the interaction that such organic compounds show with thematerials used as the receptor layer often does not take place at all ordoes so only weakly. Optical sensors are therefore frequently used as analternative for detecting such compounds. However, these may be highlysensitive to shocks and other mechanical effects. In addition, theyoften are relatively large.

SUMMARY OF THE INVENTION

Based on this, an object of the present invention is, among otherthings, to overcome these and other drawbacks of the state of the artand to provide an improved gas sensor. For example, a gas sensor shallbe provided that can be suitable for use in a PAM. It is desirable inthis connection that volatile organic compounds, especially benzene, beable to be detected with certainty and reliably by means of such asensor.

In a gas sensor in which the gas sensor has a measuring channel with agas inlet and with a gas outlet, at least one receptor layer, areference electrode and an analysis unit,

-   wherein the reference electrode is capacitively coupled with the    receptor layer,-   wherein the reference electrode is connected to the analysis unit in    an electrically conductive manner,-   wherein the receptor layer is formed in the measuring channel,-   wherein the measuring channel forms a dielectric layer between the    receptor layer and the reference electrode, and-   wherein the receptor layer has a support and an analyte-binding    layer, provisions are made according to the present invention for    the analyte-binding layer to be a self-assembling monolayer, which    consists of molecules according to the general formula

R′—R²—X,

in which R¹ is a coupling group, selected from the group containingsulfide, disulfide, sulfinyl, sulfino, sulfo, carbonothiol, thiosulfate,thiocyanate, isothiocyanate, preferably sulfide or thiosulfate, andwherein the molecules of the self-assembling monolayer are coupled eachto the support via R¹;

-   wherein the support is a layer consisting of metal, wherein the    metal is selected from the group containing gold, platinum,    palladium, silver and copper;-   wherein R² is a spacer, selected from the group containing alkane,    alkene, alkyne, heteroalkane, heteroalkene, heteroalkyne,    substituted alkanes, substituted alkenes, substituted alkynes,    substituted heteroalkanes, substituted heteroalkenes, substituted    heteroalkynes, ethers, amines; and-   wherein X is an organic or organometallic group, which can interact    with analyte molecules, especially an organic or organometallic    group with at least one delocalized π system.

In other words, the analyte-binding layer may be a self-assemblingmonolayer, which consists of molecules according to the general formula

R′—R²—X,

wherein R¹ is a coupling group, selected from the group containingsulfide, disulfide, sulfinyl, sulfino, sulfo, carbonothiol, thiosulfate,thiocyanate, isothiocyanate, preferably sulfide or thiosulphate, andwherein the molecules of the self-assembling monolayer are coupled eachvia an R¹ to the support; wherein support is a layer consisting ofmetal, wherein the metal is selected from the group comprising gold,platinum, palladium, silver and copper; wherein R² is a spacer, selectedfrom the group containing alkane, alkene, alkyne, heteroalkane,heteroalkene, heteroalkyne, substituted alkanes, substituted alkenes,substituted alkynes, substituted heteroalkanes, substitutedheteroalkenes, substituted heteroalkynes, ethers, amines; and wherein Xis an organic or organometallic group with at least one delocalized irnsystem.

The analyte-binding layer may also be a self-assembling monolayer, whichconsists of molecules according to the general formula

R′—R²—X,

wherein R¹ is a coupling group, selected from the group containingsulfide or thiosulfate, and wherein the molecules of the self-assemblingmonolayer are coupled with the support each via R¹; wherein the supportis a layer consisting of metal, wherein the metal is selected from thegroup containing (comprising any of) gold, platinum, palladium, silverand copper; wherein R² is a spacer, selected from the group containing(comprising any of) alkane, alkene, alkyne, heteroalkane, heteroalkene,heteroalkyne, substituted alkanes, substituted alkenes, substitutedalkynes, substituted heteroalkanes, substituted heteroalkenes,substituted heteroalkynes, ethers, amines; and wherein X is an organicor organometallic group with at least one delocalized π system.

A gas to be tested (gas to be measured) can therefore flow into themeasuring channel through the gas inlet in all cases and flow out of themeasuring channel through the gas outlet. Therefore, the gas to bemeasured flows through the measuring channel as a flow of gas to bemeasured. The present invention covers both a gas sensor, through whicha flow of gas to be measured is flowing, and a gas sensor without a flowof gas to be measured. The latter may happen, for example, when the gasinlet and/or the gas outlet are closed before mounting the gas sensor,e.g., for transportation purposes or the like. The measuring channel hasin any case an inner wall, which defines the interior of the measuringchannel. According to the present invention, the receptor layer is partof this inner wall. The receptor layer is thus part of the measuringchannel. The gas to be measured, which flows through the measuringchannel, flows along the receptor layer. The receptor layer forms asurface, which can interact with an analyte to be detected. The analyteis typically contained in the gas to be measured, which flows as a flowof gas to be measured through the measuring channel. The referenceelectrode may also be part of the inner wall. The flow of gas to bemeasured or the measured gas can therefore flow through the measuringchannel between the receptor layer and the reference electrode.

The receptor layer is a surface area of a capacitor in this connection.The capacitor is preferably formed by the receptor layer, the referenceelectrode and the flow of gas to be measured, which acts as a dielectricand by the volume of the measuring channel between the receptor layerand the reference electrode, which volume acts as a dielectric. Thereference electrode is thus coupled capacitively with the receptorlayer. For example, the receptor layer and the reference electrode maybe formed on mutually opposite sides of the measuring channel,preferably on opposite sides of the inner side of the measuring channel.The gas to be measured, i.e., the gas to be tested, flows through themeasuring channel, so that the flow of gas to be measured flows throughbetween the receptor layer and the reference electrode. The measuringchannel therefore forms a volume between the two surfaces of thecapacitor, which volume can act as a dielectric both when gas beingmeasured flows through the measuring channel and when the measuringchannel is empty, i.e., in the rather unlikely case in which, e.g., avacuum is present in the measuring channel. The measuring channel thusacts as a dielectric between the capacitor areas, i.e., the measuringchannel forms a dielectric layer. It is favorable in this connection ifthe measuring channel can be heated. In addition, it is advantageous ifthe measuring channel is pressure-proof.

The measuring channel may be defined by a cover and an insulation layer.Such a cover and such an insulation layer define at least one part ofthe volume of the measuring channel. The receptor layer may be formed onthe cover. The reference electrode may be embedded in the insulatorlayer. The analysis unit may likewise be embedded in the insulationlayer.

The analysis unit is either current-controlled or voltage-controlled,but it is preferably voltage-controlled. A voltage-controlled analysisunit may be in this connection, for example, a transistor or alsoanother voltage-controlled electronic component, e.g., avoltage-controlled oscillator or the like. It is essential in thisconnection that the voltage-controlled analysis unit can detect andprocess changes in the capacitance of the capacitor without the flow ofa current being necessary. If an interaction occurs between an analyteand the receptor layer, the work function (i.e., the energy that must beexpended to detach an electron from a corresponding material layer) willchange on the receptor layer and there will consequently be a change inthe capacitance of the capacitor. The latter change can be detected bythe voltage-controlled analysis unit especially if the referenceelectrode is connected to the voltage-controlled analysis unit in anelectrically conductive manner.

It was found that it is especially favorable if the receptor layercomprises a support and an analyte-binding layer. The analyte-bindinglayer may interact with both the analyte to be detected and the support.An interaction of the analyte-binding layer with an analyte preferablyleads to a change in the work function of the support and consequentlyto the detectable change in capacitance already described above. It isespecially advantageous in this connection if the analyte-binding layeris a self-assembling monolayer (self-assembling monolayer, SAM). ThisSAM forms the layer that interacts with the analyte to be detected andto which the analyte can bind preferably reversibly (on which it canpreferably be deposited).

A self-assembling monolayer (SAM) is typically a layer whose thicknesscorresponds to one molecule of the material forming the layer. Thematerial forming the layer is usually an organic compound. The moleculesof a SAM are arranged spontaneously by adsorption on a surface and areoriented in relation to one another in a more or less ordered manner dueto interaction with one another. The support of the receptor layer formsaccording to the present invention the surface on which the SAM isarranged and oriented. The support and the analyte-binding layer, i.e,the SAM, are preferably bound covalently to one another.

The gas sensor according to the present invention is characterized,furthermore, especially advantageously in that the receptor layerconsists of a support, on the surface of which a SAM is formed, whosemolecules correspond to the formula R¹R²—X. While the coupling group isused to bind the molecules of the SAM and to arrange them on thesupport, the spacer

R² is used to maintain the molecules in a certain order among oneanother. X designates in this connection the reactive group of themolecule R¹—R²—X. Analytes to be detected can interact with thisreactive group. Just as the spacer as well, the reactive group may,moreover, affect the arrangement of the molecules of the SAM.

A special advantage according to the present invention is that X may bean organic or organometallic group with at least one delocalized πsystem. Relatively inert volatile organic compounds, e.g., benzene, can,in particular, also interact with the SAM in this manner.

A delocalized π system is typically defined here as molecular orbitalsthat extend over a plurality of C atoms and in which the electrons canmove relatively freely. Mesomeric effects are characteristic ofdelocalized π systems. A mesomeric effect is the influencing of theelectron distribution in such a system by atoms that attract the πbinding electrons to themselves (electron-attracting effect, −M effect)or provide π binding electrons (electron pushing effect, +M effect).

This π system may interact, for example, with a delocalized π system ofa corresponding analyte. The analyte may be added to the reactive groupX and bring about a shift of the π electrons. The pushing of the πelectrons leads to a change in the dipole moment of the moleculesinvolved and consequently to a desired and measurable change in the workfunction.

The addition of the analyte to the X group preferably takes place viaintermolecular interactions, for example, by the action of Van der Waalsforces or by hydrogen bridges. It is conceivable that the intermolecularinteraction between the analyte molecules and the reactive group X leadsto stabilization of a complex. The pushing of the π electrons especiallyin the X group or the change in the dipole moments of the participatingmolecules can be transmitted to the support by means of electron-pushingor electron-attracting effects by substituents on the X group via thespacer R² and the coupling group R¹, as a result of which there willultimately be a change in the work function.

It is favorable in this connection if R² is a spacer, which is selectedfrom the group containing alkane, alkene, alkyne, heteroalkane,heteroalkene, heteroalkyne, substituted alkanes, substituted akenes,substituted alkynes, substituted heteroalkanes, substitutedheteroalkenes, substituted heteroalkynes, ethers or amines. The distancebetween the support or the coupling group and the reactive group can bedetermined by means of such a spacer. It is therefore advantageous ifthe spacer is a linear molecule or a linear molecular group. Forexample, the spacer may have a linear atomic chain as a backbone, whichconsists of carbon atoms or a mixture of carbon, oxygen and nitrogenatoms. The atoms of the linear atomic chain may be connected to oneanother by single, double and/or triple bonds. Thus, the spacer may be,for example, an alkane, alkene, alkyne or even a heteroalkane,heteroalkene or heteroalkyne. In addition, substituents, which support,for example, the transmission of the dipole change from the reactivegroup X to the coupling group R¹, may be bound to the backbone. Thesesubstituents may lead to interactions between adjacent spacers. Theorder and stability of the SAM can also be supported and influenced inthis manner by means of the spacer. It may therefore also beadvantageous if the spacer is a substituted alkane, substituted alkene,substituted alkyne or even a substituted heteroalkane, substitutedheteroalkene or substituted heteroalkyne.

It was found that it is, in addition, advantageous if R¹ is a couplinggroup that is selected from the group containing sulfide, disulfide,sulfinyl, sulfino, sulfo, carbonothiol, thiocyanate, isothiocyanate,preferably sulfide or thiosulfate. The individual molecules of the SAMcan interact with the metal atoms arranged on the surface of the supportby means of such a coupling group and form a covalent bond. It isespecially advantageous if the coupling group has at least one sulfuratom, which brings about the binding of the coupling group R¹ to thesurface of the support. Each coupling group R¹ preferably forms a bondwith exactly one surface atom of the support. It is thus seen that it isfavorable if the support is a layer consisting of metal, the metal beingselected from the group containing gold, platinum, palladium, silver andcopper.

In any case, it is favorable in a gas sensor according to the presentinvention if the support is a layer consisting of gold or comprised ofgold. SAMs can be arranged especially well on a gold layer. Such asupport is therefore well suited for being coated with a SAM as ananalyte-binding layer. In addition, gold can interact especially wellwith sulfur compounds. A gold layer can, in addition, be prepared withhigh purity and is especially insensitive to oxidation.

In addition, it is advantageous if the coupling group R¹ is boundcovalently to the spacer R² and to the support. The coupling group R¹can control in this manner the arrangement of the individual moleculeson the support and anchor the SAM molecules in their positions on thesupport.

It is favorable for such a binding of the SAM molecules if the couplinggroup R¹ forms at least one sulfur bridge between the spacer and thesupport. A coupling of the SAM molecules via a sulfur bridge isadvantageous especially if the support consists of gold. It is thusfavorable if R² is selected from the group containing sulfide orthiosulfate. Thiol groups, in particular, have a high affinity for noblemetals, especially gold. It is therefore especially advantageous if R¹is a sulfide radical.

It is advantageous in another aspect that R² is selected from the groupcontaining alkanes, alkenes, alkynes, substituted alkanes, substitutedalkenes, substituted alkynes, ethers, amines, wherein the substituentsof the substituted alkanes, alkenes or alkynes are selected from thegroup containing hydrogen, alkyl or aryl. It is also conceivable as analternative that R² is selected from the group containing heteroalkenes,heteroalkynes, substituted heteroalkenes and substituted heteroalkynes.

It is favorable in any case if the length of the atomic chain that formsthe backbone of the spacer R² is shorter than or equal to 40 atoms. Itis preferable in this respect if the length of the atomic chain equals5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 atoms, especially preferably 6,7, 8, 9, 10, 11 or 12 atoms and especially preferably 6, 7, 8, 9 or 10atoms.

It is thus seen that it is favorable if R² is a linear molecular groupcorresponding to the formula (Y)_(n), in which n ∈ {0, . . . , 40}_(z),wherein each Y is selected, independently from the other Y values of therespective R², from the group containing CH₂, CH, C, CR³, O, N, NR³, andwherein R³ is selected from the group containing H, alkane, alkene,alkyne or an aromatic compound. Y designates here the elements orradicals of R³, which form the linear atomic chain of the spacerbackbone. It is thus conceivable, for example, that R² is a moleculargroup corresponding to the formula (CH₂)₄(CH)₂(CH₂)₆, which would berepresented as (Y)₁₂, wherein Y would be selected in this case fromamong CH₂ and CH. A molecule of a corresponding SAM could be representedin this case according to the formula as R¹—R²—X correspondingly asR¹—(Y)₁₂—X, wherein Y is CH₂ or CH, or as R¹—(CH₂)₄(CH)₂(CH₂)₆—X. It isapparent that this example is only used to explain the notation of theformula and does not in any way represent a limitation of the presentinvention. The set of possible and conceivable combinations for theradicals Y of the spacer R² is rather obtained from the set of differentconceivable lengths of the chains formed by Y and from the selection ofthe conceivable radicals for Y, which were described above. It isespecially preferred in this connection if n ∈ {5, . . . , 15}_(z),preferably n ∈ {6, . . . , 10}_(z). The formula

R¹—R²—X

of the molecules of the SAM can therefore also be represented in apreferred embodiment variant as

R¹—(Y)_(n)—X,

in which n ∈ {0, . . . , 20}_(z), preferably n ∈ {5, . . . , 15}_(z),and especially preferably n ∈ {6, . . . , 10}_(z).

It is advantageous if R² is selected such that the spacers of adjacentmolecules interact with one another by Van der Waals forces. The spacerscan stabilize the SAMs especially well in this manner. In particular,the spacers can contribute in this manner to the reactive groups X ofadjacent molecules being oriented in a favorable position in relation toone another, so that analytes to be detected can effectively interactwith the SAM. For example, the reactive groups X may be oriented suchthat a corresponding analyte to be detected is intercalated between thereactive groups X of two adjacent molecules, and this intercalationbrings about a change in the dipole moment of the molecules of the SAM.It is also conceivable in this connection that the spacers of adjacentmolecules are bound covalently to one another. A covalent binding may beformed both along the entire chain of R² and between individual segmentsof the chain of R².

It is seen, on the whole, that the SAM may have a great variety ofdifferent combinations of the groups R¹ and R². In an especiallypreferred embodiment variant, R¹ is a sulfur-containing radical, e.g., asulfide group, and R² is an alkane, alkene or alkyne, wherein thealkane, alkene or alkyne may have as an option one or more substituentsand a length of up to 40 atoms, preferably 6 to 12 atoms, and especiallypreferably 6 to 10 atoms, along its longest chain. Thus, R² ispreferably a radical corresponding to (Y)_(n). It is especiallypreferred in this respect if R¹—R₂ is an alkane thiol, alkene thiol oralkyne thiol, optionally a substituted alkane thiol, alkene thiol oralkyne thiol, with a corresponding chain length. Such thiol compounds(thio alcohols) may generally also be called mercaptan compounds. Inother words, in an especially preferred embodiment, the startingmolecules of the SAM correspond, for example, to the formula

HS—(Y)_(n)—X.

It is favorable in all these conceivable variants for R¹ and R² or R¹—R²if the delocalized π system of the reactive group X according to thepresent invention is selected from the group containing conjugated πsystems with carbon atoms as binding centers, cyclically conjugated πsystems, π systems of radicals with a plurality of cyclically conjugatedit systems. The cyclically conjugated π systems are bound via at leastone linker in radicals that have a plurality of such systems. Thecyclically conjugated it systems are preferably planar cyclic compounds,i.e., consequently planar, cyclically conjugated π systems. The planar,cyclically conjugated π systems of aromatic or heteroaromatic systemsare especially preferred. If the reactive group X is a radical that hasa plurality of such cyclic planar it systems, which are bound via alinker, the linker is preferably selected from the group containing C,azo group, linear conjugated π system or a metallic central ion, whichcoordinates the cyclic conjugated π systems as a metal complex. It isalso favorable in this connection if the entire group X is a planargroup. In any case, X may have both electron-attracting andelectron-pushing substituents. In a preferred embodiment variant, X isan aromatic or heteroaromatic radical or a radical containing at leastone aromatic or heteroaromatic group. It is also conceivable in thisconnection, in particular, that X is a substituted aromatic orheteroaromatic radical.

X may be an aromatic or heteroaromatic radical with at least oneelectron-attracting substituent. A corresponding electron-attractingsubstituient may preferably be selected from the group containing COOR⁴,COOH, CHO, C═(O)R⁴, CN, CH═CH—COOH, NO₂, SO₃H, CF₃, especiallypreferably from the group containing CF₃, CN, NO₂, wherein R⁴ isselected from the group containing H, aryl, alkyl, heteroaryl andheteroalkyl.

It is also conceivable that X is an aromatic or heteroaromatic radicalcontaining at least one electron-pushing substituent. A correspondingelectron-pushing substituent may preferably be selected from the groupcontaining NH₂, NR⁵ ₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC═(O)R⁵, aryl, Br,Cl, I, F, especially preferably selected from the group containing CH₃,OCH₃, NH₂, wherein R⁵ is selected from the group containing H, aryl,alkyl, heteroaryl, heteroalkyl and halide.

An aromatic or heteroaromatic radical according to the present inventionmay be selected, for example, from the group containing furane, pyrrole,thiophene, imidazole, pyrazole, oxazole, isoxazole, thiazole,benzofurane, isobenzofurane, indole, isoindole, benzothiophene,benzimidazole, purine, indazole, benzoxazole, benzisoxazole,benzothiazole, benzene, pyridine, pyrazine, pyrimidine, pyridazine,naphthalene, anthracene, quinoline, isoquinoline, chinoxaline, acridine,quinazoline, cinnoline, cinnoline and the like. Each of these radicalsmay have one or more of the above-described electron-attracting orelectron-pushing substituents.

If the π system of the radical X is a linear, conjugated π system, the Xmay be a polymethine radical or a carbonyl radical.

In an especially simple embodiment, X may be, for example, a phenylradical. The X may be an anthracene, naphthalene, furane, indole,pyridine, pyrimidine or pyrrole radical. As an alternative the X may bea substituted phenyl radical, wherein the substituent is selected fromthe group containing COOR⁴, COOH, CHO, C═(O)R⁴, CN, CH═CH—COOH, NO₂,SO₃H, CF₃, especially preferably from the group containing H, aryl,alkyl, heteroaryl and heteroalkyl. This is especially favorable if R¹ isa thiole group and R² is a radical corresponding to (Y). with n E {0, .. . , 40}_(z), n ∈ {5, . . . , 15}_(z), especially preferably n ∈ {6, .. . , 10}_(z). The molecules of the SAM may therefore correspond to theformula

R⁶ is preferably hydrogen or one or more electron-pushing radicals fromthe group containing NH₂, NR⁵ ₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC═(O)R⁵,aryl, Br, Cl, I, F, especially preferably from the group containing CH₃,OCH₃, wherein R⁵ is selected from the group containing H, aryl, alkyl,heteroaryl, heteroalkyl and halide.

R⁷ is preferably hydrogen or an electron-attracting radical from thegroup containing COOR⁴, COOH, CHO, COR⁴, CN, CH═CH—COOH, NO₂, SO₃H, CF₃,especially from the group containing CF₃, CN, NO₂, wherein R⁴ isselected from the group containing H, aryl, alkyl, heteroaryl andheteroalkyl.

(Y)_(n) is preferably defined as above, wherein n is preferably n ∈ {0,. . . , 40}_(z), especially preferably n ∈ {5, . . . , 15}_(z), andespecially preferably n ∈ {6, . . . , 10}_(z). It is advantageous inthis connection if Y is selected from the group containing alkane,alkene, alkyne, substituted alkane, substituted alkene, substitutedalkyne, ether or amine, wherein the substituents are selected from thegroup containing hydrogen, alkyl or an aromatic, especially preferablyhydrogen or alkyl groups. An especially preferred embodiment of the SAMmolecules therefore corresponds to the formula

In another embodiment the X may be a polymethine radical, i.e., aconjugated polyene, in which an electron acceptor is linked to anelectron donor via an odd-numbered chain of methine groups. For example,X may be a group corresponding to the formula

wherein A is an electron acceptor, D is an electron donor, R is hydrogenor alkyl and n is an integer or zero. Here, X is preferably boundcovalently to the spacer R² via one of the radicals R. This isespecially favorable if R¹ is a thiol group and R² is a radicalcorresponding to (Y)_(n) with n ∈ {0, . . . , 40} _(z), preferably n ∈{5, . . . , 15}_(z), and especially preferably n ∈ {6, . . . , 10}_(z).The molecules of the SAM can therefore correspond to the formula

R⁶ and D are preferably hydrogen, alkyl or an electron-pushing radicalfrom the group containing NR⁵ ₂, OCH₃, CH₃, OR⁵, NHC═(O)R⁵, OC═(O)R⁵,aryl, Br, Cl, I, F, especially preferably selected from the groupcontaining CH₃, OCH₃, NH₂, wherein R⁵ is selected from the groupcontaining H, aryl, alkyl, heteroaryl, heteroalkyl and halide.

-   R⁷ and A are preferably hydrogen, alkyl or an electron-attracting    radical from the group containing COOR⁴, COOH, CHO, C═O, CN,    CH═CH—COOH, NO₂, SO₃H, CF₃, especially preferably from the group    containing CF₃, CN, NO₂, wherein R⁴ is selected from the group    containing H, aryl, alkyl, heteroaryl and heteroalkyl.-   R⁶ and 127 are, independently from each other, especially preferably    hydrogen or an alkyl radical. m is an integer or zero.-   (Y)_(n) is preferably defined as above, wherein n is preferably n ∈    {0, . . . , 20}_(z), especially preferably n ∈ {5, . . . , 15}_(z),    and especially preferably n ∈ {6, . . . , 10}_(z). It is    advantageous in this connection if Y is selected from the group    containing alkane, alkene, alkyne, substituted alkane, substituted    alkene, substituted alkyne, ether or amine, wherein the substituents    are selected from the group containing hydrogen, alkyne or aryl,    especially preferably hydrogen or alkyl. An especially preferred    embodiment of the SAM molecules therefore corresponds to the formula

in which R³, R⁶ and R⁷ are defined as above.

In another embodiment, X may be the dye parent substance of a nitro dye,i.e., an aromatic ring, to which at least one nitro group is bound. Forexample, X may be a group corresponding to the formula

wherein R⁶, R⁷ may be hydrogen or a nitrogen-containing organic radical,which is bound to the nitrobenzyl radical via a nitrogen atom, andwherein X is preferably bound to the spacer R² covalently via thisradical R⁶ or R⁷ or an additional carbon atom of the ring. This isespecially favorable if R¹ is a thiol group and R² is a radicalcorresponding to (Y)_(n) with n ∈ {0, . . . , 40}_(z). preferably n ∈{5, . . . , 15}_(z) and especially preferably n ∈ {6, . . . , 10}_(z).The molecules of the SAM may therefore correspond to the formula

R⁶ is preferably hydrogen or an electron-pushing radical from the groupcontaining NR⁵ ₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC═(O)R⁵, aryl, Br, Cl,I, F, especially preferably selected from the group containing CH₃,OCH₃, NH₂, wherein R⁵ is selected from the group containing H, aryl,alkyl, heteroaryl, heteroalkyl and halide.

-   R⁷ is preferably hydrogen or an electron-attracting radical from the    group containing COOR⁴, COOH, CHO, C(O)R⁴, CN, CH═CH—COOH, NO₂,    SO₃H, CF₃, especially preferably from the group containing CF₃, CN,    NO₂, wherein R⁴ is selected from the group containing H, aryl,    alkyl, heteroaryl and heteroalkyl.-   R⁶ and R⁷ are, independently from one another, especially preferably    either hydrogen or a radical corresponding to NR⁵R⁴, NO₂, NHC═(O)R⁵,    NR⁵ ₂ or NH₂, in which R⁵, R⁴ are defined as above. (Y)_(n) is    preferably as defined above, n preferably being n ∈ {0, . . . ,    40}_(z), especially preferably n ∈ {5, . . . , 15}_(z), and    especially preferably n ∈ {6, . . . , 10}_(z). It is advantageous in    this connection if Y is selected from the group containing alkane,    alkene, alkyne, substituted alkane, substituted alkene, substituted    alkyne, ether or amine, wherein the substituents are selected from    the group containing hydrogen, alkyl or aryl, especially preferably    hydrogen or alkyl. An especially preferable embodiment of the SAM    molecules therefore corresponds to the formula

It is also conceivable in yet another embodiment that X is the dyeparent substance of an azo dye, in which at least two aromatic rings arelinked via an azo group. For example, X may be a group corresponding tothe formula

in which R⁶ and R⁷ may each be, independently from one another,hydrogen, aryl, alkyl or a nitrogen-containing organic radical. This isespecially favorable if R¹ is a thiol group and R² is a radicalcorresponding to (Y)_(n) with n ∈ {0, . . . , 40}_(z), preferably n ∈{5, . . . , 15}_(z) and especially preferably n ∈ {6, . . . , 10}_(z).The molecules of the SAM may therefore correspond to the formula

R⁶ is preferably hydrogen or an electron-pushing radical from the groupcontaining NR⁵ ₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC═(O)R⁵, aryl, Br, Cl,I, F, especially preferably selected from the group containing CH₃,OCH₃, NH₂, wherein R⁵ is selected from the group containing H, aryl,alkyl, heteroaryl, heteroalkyl and halide.

-   R⁷ is, independently from R⁶, preferably hydrogen or an    electron-attracting radical from the group containing COOR⁴, COOH,    CHO, C(O)R⁴, CN, CH═CH—COOH, NO², SO₃H, CF₃, especially preferably    from the group containing CF₃, CN, NO₂, wherein R⁴ is selected from    the group containing H, aryl, alkyl, heteroaryl and heteroalkyl.-   R⁶ and R⁷ are, independently from one another, especially preferably    either hydrogen, aryl, alkyl or a radical corresponding to NR⁵R⁴,    NO₂, NHC═(O)R⁵, NR⁵ ₂ or NH₂, with R⁵, R⁴ as defined above.-   (Y)_(n) is preferably as defined above, wherein n is preferably n ∈    {0, . . . , 40}_(z), especially preferably n ∈ {5, . . . , 15}_(z)    and especially preferably n ∈ {6, . . . , 10}_(z). It is    advantageous in this connection if Y is selected from the group    containing alkane, alkene, alkyne, substituted alkane, substituted    alkene, substituted alkyne, ether or amine, wherein the substituents    are selected from the group containing hydrogen, alkyl and aryl,    especially preferably hydrogen and alkyl. An especially preferred    embodiment of the SAM molecules therefore corresponds to the formula

It is conceivable in another embodiment that the reactive group X is adye parent substance of a carbnonyl dye. At least two carbonyl groupsare conjugated via one or more 7E bonds in such a radical. For example,X may be a group corresponding to the formula

wherein R⁶ and R⁷ may each be, independently from one another, hydrogen,aryl, alkyl or a nitrogen-containing organic radical. m is an integer orzero. This is especially favorable if R¹ is a thiol group and R² is aradical corresponding to (Y)_(n) with n ∈ {0, . . . , 40}_(z),preferably n ∈ {5, . . . , 15}_(z) and especially favorably n ∈ {6, . .. , 10}_(z). The molecules of the SAM may therefore correspond to theformula

Here, R⁶ is especially favorably hydrogen or an electron-pushing radicalfrom the group containing NR⁵ ₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC═(O)R⁵,aryl, Br, Cl, I, F, especially preferably selected from the groupcontaining CH₃, OCH₃, NH₂, wherein R⁵ is selected from the groupcontaining H, aryl, alkyl, heteroaryl, heteroalkyl and halide.

-   R⁷ is, independently from R⁶, preferably hydrogen or an    electron-attracting radical from the group containing COOR⁴, COOH,    CHO, C(O)R₄, CN, CH═CH—COOH, NO₂, SO₃H, CF₃, especially from the    group containing CF₃, CN, NO₂, wherein R⁴ is selected from the group    containing H, aryl, alkyl, heteroaryl and heteroalkyl.-   R₆ and R⁷ are, independently from each other, especially preferably    either hydrogen or aryl. (Y)_(n) is preferably defined as above,    wherein n is preferably n ∈ {0, . . . , 40}_(z), especially    preferably n ∈ {5, . . . , 15}_(z) and especially preferably n ∈ {6,    . . . , 10_(z). It is advantageous in this connectioon if Y is    selected from the group containing alkane, alkene, alkyne,    substituted alkane, substituted alkene, substituted alkyne, ether or    amine, wherein the substituents are selected from the group that    contains hydrogen, alkyl or aryl, especially preferably hydrogen or    alkyl groups. An especially preferred embodiment of the SAM    molecules therefore corresponds to the formula

It is conceivable in another embodiment that the reactive group X is adye parent substance of a triarylcarbenium dye. Such dye parentsubstances are derivatives of triphenylmethane. For example, X maycontain a group corresponding to the formula

wherein R⁶ and R⁷ may be each, independently from one another, hydrogen,aryl, alkyl or a nitrogen-containing organic radical. m is selected from0 or 1. W is hydrogen or a nitrogen-containing organic radical. This isespecially favorable if R¹ is a thiol group and R² is a radicalcorresponding to (Y). with n ∈ {0, . . . , 40}_(z), preferably n ∈ {5, .. . , 15}_(z) and especially preferably n ∈ {6, . . . , 10}_(z). Themolecules of the SAM may therefore correspond to the formula

R⁶ is preferably hydrogen or an electron-pushing radical from the groupcontaining NR⁵ ₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC═(O)R⁵, aryl, Br, Cl,I, F, especially preferably selected from the group containing CH₃,OCH₃, NH₂, wherein R⁵ is selected from the group containing H, aryl,alkyl, heteroaryl, heteroalkyl and halide.

R⁷ is, independently from R⁶, preferably hydrogen or an electron-pushingradical from the group containing COOR⁴, COOH, CHO, C(O)R⁴, CN,CH═CH—COOH, NO₂, SO₃H, CF₃, especially preferably from the groupcontaining CF₃, CN, NO₂, wherein R⁴ is selected from the groupcontaining H, aryl, alkyl, heteroaryl, heteroalkyl.

-   R⁶ and R⁷ are especially preferably, independently from one another,    either a nitrogen-containing organic radical according to the    formula NR⁴R⁵, oxygen or a hydroxyl group, with R⁴ and R⁵ as defined    above.-   (Y)_(n) is preferably as defined abvove, wherein n is preferably n ∈    {0, . . . , 40}_(z), especially preferably n ∈ {5, . . . , 15}_(z)    and especially preferably n ∈ {6, . . . , 10}_(z). It is    advantageous in this connection if Y is selected from the group    containing alkane, alkene, alkyne, substituted alkane, substituted    alkene, substituted alkyne, ether or amine, wherein the substituents    are selected from the group that contains hydrogen, alkyl or aryl,    especially preferably hydrogen or alkyl. An especially preferred    embodiment of the SAM molecules therefore corresponds to the formula

It is conceivable in another embodiment that the reactive group X is thedye parent substance of an anthocyanidine dye. Such dye parentsubstances are hydroxylated derivatives of the flavylium ion. X may be,for example, a group corresponding to the formula

wherein R⁶ and R⁷ may be each, independently from one another, hydrogenor a hydroxyl radical. However, at least one radical R⁶ or R⁷ is ahydroxyl radical. This is especially favorable if R¹ is a thiol groupand R² is a radical corresponding to (Y)_(n), in which n ∈ {0, . . . ,40}_(z), preferably n ∈ {5, . . . , 15}_(z) and especially preferably n∈ {6, . . . , 10}_(z). The molecules of the SAM may therefore correspondto one of the formulas

R⁶ and R⁷ are preferably hydrogen or an electron-pushing radical fromthe group containing OCH₃ or OH, especially preferably selected from thegroup containing OCH₃ and OH. Independently from one another, R⁶ and R⁷are especially preferably either hydrogen or a hydroxyl radical.

-   (Y)_(n) is preferably as defined above, wherein n is preferably n ∈    {0, . . . , 40}_(z), especially preferably n ∈ {5, . . . , 15}_(z)    and especially preferably n ∈ {6, . . . , 10}_(z). It is    advantageous in this connection if Y is selected from the group    containing alkane, alkene, alkyne, substituted alkane, substituted    alkene, substituted alkyne, ether or amine, wherein the substituents    are selected from the group containing hydrogen, alkyl and aryl,    especially preferably hydrogen and alkyl. An especially preferred    embodiment of the SAM molecules therefore corresponds to the formula

It is conceivable in another embodiment that the reactive group X is thedye parent substance of a metal complex dye, e.g., of aphthalocyanine-copper complex. For example, X may be a groupcorresponding to the formula

wherein R⁶ and R⁷ may be each, independently from one another, hydrogenor halogen. This is especially favorable if R¹ is a thiol group and R²is a radical corresponding to (Y)_(n), in which n ∈ {0, . . . , 40}_(z),preferably n ∈ {5, . . . , 15}_(z) and especially preferably n ∈ {6, . .. , 10}_(z). The molecules of the SAM may therefore correspond to theformula

R⁶ and R⁷ are preferably hydrogen or halogen.

-   R⁶ and R⁷ are especially preferably hydrogen.-   (Y)_(n) is preferably defined as above, n preferably being n ∈ {0, .    . . , 40}_(z), preferably n ∈ {5, . . . , 15}_(z) and especially    preferably n ∈ {6, . . . , 10}_(z). It is advantageous in this    connection if Y is selected from the group containing alkane,    alkene, alkyne, substituted alkane, substituted alkene, substituted    alkyne, ether or amine, wherein the substituents are selected from    the group containing hydrogen, alkyl or aryl, preferably hydrogen    and alkyl, especially preferably hydrogen groups. An especially    preferred embodiment of the SAM molecules therefore corresponds to    the formula

In other words, X is preferably selected from the group containingpolyenes, nitro dyes, azo dyes, triphenylmethane derivatives,anthocyanidines, and phthalocyanine-metal complexes. It is alsoconceivable as an alternative that X is selected from the groupcontaining aryl radicals, which are selected from the group containingphenyl, benzyl, pyridyl, anthraquinones, and naphthalene. It isespecially advantageous in this connection that X is a radicalcontaining at least one electron-attracting substituent, wherein theradical is selected from the group containing polymethine, arylradicals, metal complexes, macrocyclic arenyl radicals and dendrimers,and wherein the substituent is preferably selected from the groupcontaining COOR⁴, COOH, CHO, COR⁴, CN, CH═CH—COOH, NO₂, SO₃H, CF₃,especially preferably from the group containing CF₃, CN, NO₂, wherein R⁴is selected from the group containing H, aryl, alkyl, heteroaryl, andheteroalkyl. It may also be favorable that X is a radical containing atleast one electron-pushing substituent, wherein the radical is selectedfrom the group containing polymethine, aryl radicals, metal complexes,macrocyclic arenyl radicals and dendrimers, and wherein the substituentis preferably selected from the group containing NR⁵ ₂, OCH₃, CH₃, OH,OR, NHC═(O)R⁵, OC(O)R⁵, aryl, Br, Cl, I, F and especially selected fromthe group containing CH₃ and OCH₃, wherein R⁵ is selected from the groupcontaining H, aryl, alkyl, heteroaryl, heteroalkyl and halide.

In a preferred embodiment of the present invention, thevoltage-controlled analysis unit is a field-effect transistor, thefield-effect transistor of the gas sensor according to the presentinvention being especially a capacitively controlled field-effecttransistor (CCFET).

It is advantageous in this connection if the reference electrode isconnected to the gate electrode of the field-effect transistor. A changein capacitance between the receptor layer and the reference electrodecan bring about a change in the charge transport between the source anddrain of the FET in this manner. This change in the flow of current canultimately be used, for example, to trigger an alarm or the like.

In another aspect, the present invention provides a gas-measuring devicewith a gas sensor according to the present invention. In addition, thepresent invention provides for the use of a gas sensor according to thepresent invention for detecting volatile organic compounds, preferablybenzene and/or benzene derivatives.

Further features, details and advantages of the present invention appearfrom the wording of the claims as well as from the following descriptionof exemplary embodiments on the basis of the drawings.

The present invention is described in detail below with reference to theattached figures. The various features of novelty which characterize theinvention are pointed out with particularity in the claims annexed toand forming a part of this disclosure. For a better understanding of theinvention, its operating advantages and specific objects attained by itsuses, reference is made to the accompanying drawings and descriptivematter in which preferred embodiments of the invention are illustrated.

BRIEF DESCRIPTION OF THE DRAWINGS

In the drawings:

FIG. 1 is a schematic view of a gas sensor according to the presentinvention;

FIG. 2 is a schematic view of the receptor layer;

FIG. 3a is a view showing one of different examples for the reactivegroup X of the SAM molecules;

FIG. 3b is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 3c is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 3d is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 3e is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 3f is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 3g is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 3h is a view showing another of different examples for the reactivegroup X of the SAM molecules;

FIG. 4 is a schematic view of an analyte binding in a gas sensoraccording to the present invention; and

FIG. 5 is the detection of benzene by means of a gas sensor according tothe present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring to the drawings, the gas sensor 10 according to the presentinvention shown in FIG. 1 has a measuring channel 11, which is coveredby a cover 14 and has a gas inlet 12 as well as a gas outlet 13. Thevolume of the measuring channel 11 is defined by the inner wall 111. Aflow of gas to be measured M can flow through this volume to the gasoutlet 13 and flow along the inner wall 111 in the process.

It is seen, in addition, in FIG. 1 that a receptor layer 20 is arrangedin the interior of the measuring channel 11. The receptor layer 20 isapplied to the cover 14. It comprises a support 21 and ananalyte-binding layer 22. The receptor layer 20, especially theanalyte-binding layer 22, forms here a part of the inner wall 111 of themeasuring channel 11. A reference electrode 30 is arranged opposite thereceptor layer 20. The receptor layer 20, the reference electrode 30 andthe volume of the measuring channel 11 formed between the receptor layer20 and the reference electrode 30 form a capacitor 40. It is seen inthis respect that the reference electrode 30 is capacitively coupledwith the receptor layer 20. The capacitance of this capacitor 40 can bechanged by interactions of the analyte-binding layer 22 with an analytecontained in the measured gas flow M.

It is seen, furthermore, in FIG. 1 that the reference electrode 30 isconnected to a voltage-controlled analysis unit 50 via an electricallyconductive connection 31. The voltage-controlled analysis unit 50 is afield-effect transistor, namely, a CCFET, in the example being shown.The analysis unit 50 has in this respect a source electrode 51, a drainelectrode 52 and a gate electrode 53. The reference electrode 30 isconnected to the gate electrode 53. The gate electrode 53 is arrangedabove a channel 54, which connects the source electrode 51 and the drainelectrode 52 to one another. The gate electrode 53 determines the chargeflow, which takes place between the drain electrode and the sourceelectrode 51, 52 through the channel 54 as a function of the capacitanceof the capacitor 40.

The reference electrode 30 is embedded in an insulation layer 60 in theexemplary embodiment being shown. The analysis unit 50 is arrangedbetween the insulation layer 60 and the substrate 61. The insulationlayer 60 can help avoid or at least minimize false signals.

FIG. 1 shows in this respect a gas sensor 10, wherein the gas sensor 10has a measuring channel 11 with a gas inlet 12 and with a gas outlet 13,at least one receptor layer 20, a reference electrode 30 and avoltage-controlled analysis unit 50, wherein the reference electrode 30is capacitively coupled with the receptor layer 20, wherein thereference electrode 30 is connected to the analysis unit 50 in anelectrically conductive manner, wherein the receptor layer 20 is formedin the measuring channel 11, wherein the measuring channel 11 forms adielectric layer between the receptor layer 20 and the referenceelectrode 30, and wherein the receptor layer 20 has a support 21 and ananalyte-binding layer 22.

The analyte-binding layer 22 of such a gas sensor 10 is configured ascan be seen in FIG. 2 as a self-assembling monolayer (SAM). Themolecules of this SAM correspond to the general formula R¹—R²—X. It isseen that the molecules comprise three functional units, namely, thecoupling group R¹, the spacer R² and the reactive group X. The moleculesof the SAM, i.e., of the analyte-binding layer 22, are oriented on thesupport 21 in a synchronous orientation and parallel to one another. Themolecules are always coupled to the support 21 via the coupling groupR¹. The coupling group R¹ is selected from the group containing sulfide,disulfide and thiosulfate.

It is seen in FIG. 2 that the spacer R² determines the distance of thereactive group X from the coupling group R¹ and hence from the support21. The spacer R² is selected from the group containing alkane, alkene,alkyne, heteroalkane, heteroalkene, heteroalkyne, substitute alkanes,substituted alkenes, substituted alkynes, substituted heteroalkanes,substituted heteroalkenes and substituted hetreroalkynes.

The reactive group X is an organic or organometallic group. To measurebenzene, the group X has at least one delocalized π system. The support21 is a layer consisting of metal, wherein the metal is selected fromthe group containing gold, platinum, palladium, silver and copper.

FIGS. 3a through 3h show different examples of embodiments of thereactive group X. It is obvious that the present invention is notlimited to the molecules concretely shown here.

Corresponding to the exemplary embodiment shown in FIG. 3 a, thereactive group X is a phenyl radical. The reactive group X is coupledwith the radical R²—R¹ via a covalent bond between the radical R² andone of the ring atoms of the phenyl radical. R⁶ and R⁷ are as describedabove. In an especially favorable exemplary embodiment (not shown in thefigure) with such a reactive group X, the molecules of the SAMcorrespond to the formula

R⁶, R⁷, R³, n and Y being defined as described above here as well.

-   According to the exemplary embodiment according to FIG. 3 b, the    reactive group X is a nitro dye, in which a nitro group is bound to    an aromatic ring, namely, nitrophenyl. The aromatic ring may have an    additional substituent according to the general formulas NR⁴R⁵. The    reactive group X is coupled to the spacer R² via the ring. In an    especially favorable exemplary embodiment (not shown) with such a    reactive group X, the molecules of the SAM correspond to the formula

R⁶, R⁷, R³, n and Y being defined as described above here as well.

-   The reactive group X is an azo dye in FIG. 3c . The reactive group X    is coupled with the spacer R² via one of the rings. In an especially    favorable exemplary embodiment (not shown) with such a reactive    group X, the molecules of the SAM correspond to the formula

R⁶, R⁷, R³, n and Y being defined as described above here as well.

-   Corresponding to the exemplary embodiment according to FIG. 3d , the    reactive group X is a polymethine radical. The polymethine radical    may have alkyl groups or hydrogen as substituents R⁶, R⁷. The    reactive group X is coupled with the spacer R² via such a radical.    In an especially favorable exemplary embodiment (not shown) with    such a reactive group X, the molecules of the SAM correspond to the    formula

R⁶, R⁷, R³, n, m and Y being defined as described above here as well.

-   In the exemplary embodiment shown in FIG. 3e , the reactive group X    is a carbonyl dye. The reactive group X is coupled with the spacer    R² via a radical R⁶ or R⁷. In an especially favorable exemplary    embodiment (not shown) with such a reactive group X, the molecules    of the SAM correspond to the formula

s R⁶, R⁷, R³, n, m and Y being defined as described above here as well.

-   In the exemplary embodiment shown in FIG. 3f , the reactive group X    is a triarylcarbenium radical. The reactive group X is coupled with    the spacer R² via one of the rings. In an especially favorable    exemplary embodiment (not shown) with such a reactive group X, the    molecules of the SAM correspond to the formula

R⁶, R⁷, R³, n, m, W and Y being defined as described above here as well.

The reactive group is an anthocyanine derivative in FIG. 3g . Thereactive group X is coupled here to the spacer R² via one of the rings.In an especially favorable exemplary embodiment (not shown) with such areactive group X, the molecules of the SAM correspond to one of thefollowing formulas

R⁶, R⁷, R³, n and Y being defined as described above here as well.

The reactive group is a metal complex, namely, copper phthalocyanidine,in FIG. 3h . The reactive group X is coupled with the spacer R² via oneof the rings. In an especially favorable exemplary embodiment (notshown) with such a reactive group X, the molecules of the SAM correspondto the formula

R⁶, R⁷, R³, n and Y being defined as described above here as well.

It is seen in FIG. 4 how the steric arrangement of the molecules of theSAM, i.e., of the analyte-binding layer 22, may be. The molecules to thesupport 21 are coupled with the support 21 via a sulfur bridge. Thecoupling group R¹ is therefore a sulfide group. The hydrogen radicals ofthe thiol groups are split off during the coupling of the molecules,i.e., during the formation of the analyte-binding layer 22 due to theself-assembly of the molecules, and a covalent bond is formed betweenthe sulfur atoms of the coupling group R¹ and the gold atoms of thesupport 21. The sulfur atoms of the coupling group R¹ are, in addition,bound covalently to the spacer R². The spacer R² consists of a linearchain of four methylene groups in the exemplary embodiment shown in FIG.4. It should be noted here that the length of the spacer R² is between 6and 12 atoms in especially favorable embodiments. The length of thespacer is reduced to only four methylene groups in FIG. 4 solely forreasons of clarity and for the sake of a clearer illustration. Thereactive group X is bound to the methylene group of the spacer R², whichis in terminal position relative to the coupling group R¹. The reactivegroup X is a phenyl ring in this exemplary embodiment. The phenyl ringcarries a substituent R⁶, R⁷, namely, a nitro group. The SAM thereforeconsists of a layer of a substituted phenylalkyl mercaptan according tothe formula

wherein R³ is hydrogen, n=4, wherein the ring atoms of the phenylradical in ortho and meta positions carry hydrogen each as a substituentR⁶, R⁷ and wherein the aromatic ring has a nitrogen group as asubstituent in the para position.

It is further seen in the schematic view in FIG. 4 how an analyteA—benzene in the example being shown—can approach the analyte-bindinglayer 22 with the flow of gas to be measured. In the next step, thebenzene molecules of the analyte A can add plane-parallel to the phenylradicals of the reactive group X of the SAM. A charge shift can occurwithin the SAM in this manner. This shift is, in turn, detectable bymeans of the analysis unit as was described above.

FIG. 5 shows a dynamic measured curve, which was recorded by means of agas sensor 10, which has an analyte-binding layer 20 corresponding toone of the exemplary embodiments shown above. Such a measured curve canbe obtained especially by means of an analyte-binding layer 20 as shownin FIG. 4.

The change in the work function as a function of the presence of ananalyte is seen in FIG. 5. The curve T shows the work function measuredby the gas sensor 10. Curve B shows the concentration of an analyte A,here benzene. The receptor is first exposed to benzene-free air. As canbe seen on curve B, a benzene concentration of 1 ppm is admitted after17 seconds. It can further be seen that the work function has changed by5 mV immediately after the addition of benzene, namely, after about 3sec. The flow of benzene is interrupted after 57 sec. The work functiongoes back to the original initial value within 4 sec. The supply ofbenzene is restarted after 238 sec and stopped again after 264 sec. Itis seen that a reliable change occurs in the work function upon thisrepeated admission as well.

The present invention is not limited to one of the above-describedembodiments, but may be modified in many different ways.

All the features and advantages appearing from the claims, thedescription and the drawings, including design details, spatialarrangements and method steps, may be essential for the presentinvention both in themselves and in the many different combinations.

While specific embodiments of the invention have been shown anddescribed in detail to illustrate the application of the principles ofthe invention, it will be understood that the invention may be embodiedotherwise without departing from such principles.

1. A gas sensor comprising: a measuring channel with a gas inlet andwith a gas outlet; at least one receptor layer; a reference electrode;and an analysis unit, wherein: the reference electrode is capacitivelycoupled with the receptor layer; the reference electrode is connected,electrically conductively, to the analysis unit; the receptor layer isformed in the measuring channel; the measuring channel forms adielectric layer between the receptor layer and the reference electrode;and the receptor layer has a support and an analyte-binding layer; theanalyte-binding layer is a self-assembling monolayer, which is comprisedof molecules according to the general formula R¹—R²—X; R¹ is a couplinggroup, selected from the group containing sulfide, disulfide, sulfinyl,sulfino, sulfo, carbonothiol, thiosulfate, thiocyanate, isothiocyanate,preferably sulfide or thiosulfate, and wherein the molecules of theself-assembling monolayer are coupled each via R¹ to the support; thesupport is a layer comprised of metal; the metal is selected from thegroup containing gold, platinum, palladium, silver and copper; R² is aspacer, selected from the group containing alkane, alkene, alkyne,heteroalkane, heteroalkene, heteroalkyne, substitute alkanes,substituted alkenes, substituted alkynes, substituted heteroalkanes,substituted heteroalkenes, substituted heteroalkynes, ethers, amines;and X is an organic or organometallic group, which can interact with ananalyte molecule, or an organic or organometallic group with at leastone delocalized π system.
 2. A gas sensor in accordance with claim 1,wherein the support is a layer consisting of gold.
 3. A gas sensor inaccordance with claim 1, wherein the coupling group R¹ is boundcovalently to the spacer R² and to the support.
 4. A gas sensor inaccordance with claim 1, wherein the coupling group R¹ forms at leastone sulfur bridge between the spacer R² and the support.
 5. A gas sensorin accordance with claim 1, wherein R¹ is selected from the groupcontaining sulfide, disulfide or thiosulfate.
 6. A gas sensor inaccordance with claim 1, wherein R¹ is a sulfide radical.
 7. A gassensorin accordance with claim 1, wherein R² is selected from the groupcontaining alkanes, alkenes, alkynes, substituted alkanes, substitutedalkenes, substituted alkynes, ethers, amines, wherein the substituentsof the substituted alkanes, alkenes or alkynes are selected from thegroup containing hydrogen, alkyl or aryl.
 8. A gas sensor in accordancewith claim 1, wherein R² is a linear molecular group corresponding tothe formula (Y)_(n), in which n ∈ {0, . . . , 40}z, wherein each Y isselected, independently from the other Y values of the respective R²,from the group containing CH₂, CH, C, CR³, O, N, NR³, and wherein R³ isselected from the group containing H, alkane, alkene, alkyne or anaromatic.
 9. A gas sensor in accordance with claim 8, wherein n∈ {5, . .. , 15}z, preferably n ∈ {6, . . . , 10}z.
 10. A gas sensor inaccordance with claim 1, wherein the spacers R² of adjacent moleculesinteract with one another by Van der Waals forces.
 11. A gas sensor inaccordance with claim 1, wherein the spacers R² of adjacent moleculesare bound covalently to one another.
 12. A gas sensor in accordance withclaim 1, wherein the delocalized π system of group X is selected fromthe group containing conjugated π systems with carbon atoms as bindingcenters, cyclically conjugated π systems and π systems of radicals witha plurality of cyclically conjugated π systems.
 13. A gas sensor inaccordance with claim 1, wherein X is an aromatic or heteroaromaticradical with at least one electron-attracting substituent.
 14. A gassensor in accordance with claim 1, wherein X is an aromatic orheteroaromatic radical with at least one electron-pushing substituent.15. A gas sensor in accordance with claim 1, wherein X is selected fromthe group containing polyenes, nitro dyes, azo dyes, triphenylmethanederivatives, anthocyanidines phthalocyanine-metal complexes.
 16. A gassensor in accordance with claim 1, wherein X is an aryl radical,selected from the group containing phenyl, benzyl, pyridyl,anthraquinones naphthalene.
 17. A gas sensor in accordance with claim 1,wherein X is a radical with at least one electron-attractingsubstituent, wherein the radical is selected from the group containingpolymethine, aryl radicals, metal complexes, macrocyclic arenyl radicalsand dendrimers, and wherein the substituent is preferably selected fromthe group COOR⁴, COOH, CHO, COR⁴, CN, CH═CH—COOH, NO₂, SO₃H CF₃, whereinR⁴ is selected from the group containing H, aryl, alkyl, heteroaryl andheteroalkyl.
 18. A gas sensor in accordance with claim 1, wherein X is aradical with at least one electron-pushing substituent, wherein theradical is selected from the group containing polymethine, arylradicals, metal complexes, macrocyclic arenyl radicals and dendrimers,and wherein the substituent is selected from the group containing N R⁵₂, OCH₃, CH₃, OH, OR, NHC═(O)R⁵, OC(O)R⁵, aryl, Br, Cl, I, F, especiallypreferably selected from the group containing CH3 and OCH3, wherein R⁵is selected from the group containing H, aryl, alkyl, heteroaryl,heteroalkyl halide.
 19. A gas sensor in accordance with claim 1, whereinthe analysis unit is comprises a capacitively controlled field-effecttransistor (CCFET).
 20. A gas esensor in accordance with claim 19,wherein the reference electrode is connected to the gate electrode ofthe field-effect transistor.
 21. A gas sensor according to claim 1 thatforms a part of a gas-measuring device.
 22. A gas sensing methodcomprising: iding a gas sensor comprising a measuring channel with a gasinlet and with a gas outlet, at least one receptor layer, a referenceelectrode and an analysis unit wherein the reference electrode iscapacitively coupled with the receptor layer, the reference electrode isconnected, electrically conductively, to the analysis unit, the receptorlayer is formed in the measuring channel, the measuring channel forms adielectric layer between the receptor layer and the reference electrode,the receptor layer has a support and an analyte-binding layer, theanalyte-binding layer is a self-assembling monolayer, which is comprisedof molecules according to the general formula R¹—R²—X wherein R¹ is acoupling group, selected from the group containing sulfide, disulfide,sulfinyl, sulfino, sulfo, carbonothiol, thiosulfate, thiocyanate,isothiocyanate, preferably sulfide or thiosulfate, and wherein themolecules of the self-assembling monolayer are coupled each via R¹ tothe support, the support is a layer comprised of metal, the metal isselected from the group containing gold, platinum, palladium, silver andcopper, wherein R² is a spacer, selected from the group containingalkane, alkene, alkyne, heteroalkane, heteroalkene, heteroalkyne,substitute alkanes, substituted alkenes, substituted alkynes,substituted heteroalkanes, substituted heteroalkenes, substitutedheteroalkynes, ethers, amines and X is an organic or organometallicgroup, which can interact with an analyte molecule, or an organic ororganometallic group with at least one delocalized π system; anddetecting volatile organic compounds with the provided gas sensor.
 23. Agas sensing method according to claim 22, wherein the step of detectingcomprises detecting benzene and/or benzene derivatives with the providedgas sensor.